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KMID : 0369819950250030185
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Jorunal of Korean Pharmaceutical Sciences
1995 Volume.25 No. 3 p.185 ~ p.192
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Studies on the Bioavailability of Berberine Prepartions(II) : Antibacterial Activity and Bioavailability of Coprecipitate of Coptidis Rhizoma and Glycyrrhizae Radix
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Abstract
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Precipitation reaction occurred between berberine in Coptidis Rhizome and glycyrrhizin in Glycyrrhizae Radix when they were boiled together in aqueous solution and the supernatant solution thus obtained did not show any antibacterial activity
which
was
derived from berberine. The content of berberine in BG and CGP by HPLC analysis were 41.1%, 8.3% respectively. BG was occurred mostly at pH 5.0. The solubility of berberine was 0.15%, while that of BG and CGP was 0.07%, 0.12%, respectively, CGP
shown
more increased antibacterial activity to gram positive bacteria, S dysentriae and K. pneumoniae than berberine. The absorption rates of CGP in stomach. duodenum and jejunum of rats were compared wit those of Coptidis Rhizoma water extracts(CR),
which
were increased more than CR. The time required for the maximum serum concentration of berberine from CGP in mice was 90 minutes after oral administration. The maximum serum concentration of berberine from CGP was higher than that from CR. The
dissolution of CGP was increased more than berberine and BG in both artificial gastric and intestinal fluids. The dissolution of CGP pill made from gelatin was 63.4% in artificial gastric fluids and that made from CMC was 76.0% in artificial
intestinal
fluids.
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